Though Justin Langer's side were fortunate enough to face England in six white-ball matches, this series represents their first home matches since the virus hit.
With several senior players involved in the Indian Premier League and a long winter ahead, they have opted to use the limited-overs leg of India's tour to experiment.
Moises Henriques hasn't played for his country for three years but has earned a recall, while there is also a place for Cameron Green as Mitchell Marsh attempts to recapture full fitness.
Green will a fascinating watch. He has enjoyed a fine start to the Sheffield Shield for Western Australia, scoring two centuries and could be handed an early opportunity to impress. Greg Chappell has already compared him to Ricky Ponting, adding to the attention.
With several players being forced to quarantine since returning from the United Arab Emirates, and the ODIs clearly being third in the list of priorities, it could yet be an experimental period for Australia in this format.
Finch's side got the better of world champions England in September but have left out a host of players from that trip. Nathan Lyon and Riley Meredith both miss out, while Josh Philippe has only been called up for training. Andrew Tye has since replaced Kane Richardson.
The SCG and Manuka Oval will be at 50 per cent capacity for the ODIs and T20s, with all available tickets having been snapped up by fans eager to see these two sides face-off.
Cameron Green has been rewarded for a fine season with a call-up
And while these 50-over matches are merely the appetisers for the rest of the summer, the presence of supporters will punctuate the clashes with some texture.
Australia squad: Aaron Finch (c), Sean Abbott, Ashton Agar, Alex Carey, Pat Cummins (vc), Cameron Green, Josh Hazlewood, Moises Henriques, Marnus Labuschagne, Glenn Maxwell, Daniel Sams, Kane Richardson, Steven Smith, Mitchell Starc, Marcus Stoinis, Matthew Wade, David Warner, Adam Zampa
While India have not played since their first ODI against South Africa was abandoned in March, their star names returned to action in the IPL.
Rohit Sharma is missing for the white-ball matches but will return for the Test series. But otherwise, the tourists are largely at full strength for the matches.
The group includes two members of the victorious Mumbai Indians squad which romped to the IPL title. Hardik Pandya was a constant threat in the middle order as a finisher with the bat, while Jasprit Bumrah was typically a menace with the ball upfront and at the death.
There were other star performers who will hope to take their form to Australia. Shikhar Dhawan was the highest run-scorer, KL Rahul made the best individual knock, Yuzvendra Chahal was the leading spinner and Mohammad Shami took as many wickets as Jofra Archer.
Inevitably, perhaps because his involvement could be fleeting, eyes will be fixed on Virat Kohli who is only scheduled to play one of the four Tests later in the summer. With eight centuries and eight fifties in 38 innings in Australia, he, as ever, represents the key scalp.
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