The fixture, which is scheduled to take place from Saturday, will nominally be a Lancashire home match.
The Red Rose county do not have an outground available which meets the bio-secure protocols required by the ECB, while Emirates Old Trafford is currently being used by the England men's side for Test and limited-overs series against West Indies and Pakistan.
Leicester's Fischer County Ground did meet all the relevant requirements, but The Cricketer understands Lancashire were unwilling to travel into a region of the country which remains in localised lockdown following a spike in Covid-19 cases.
An ECB statement read: "Leicestershire met all protocols to safely stage the match at the Fischer County Ground, however with the city of Leicester in lockdown due to the COVID-19 pandemic, a decision was taken to schedule the match at a neutral venue."
Leicestershire will retain three home fixtures, with the scheduled visit to Durham on August 15 now moved to Leicester from Emirates Riverside.
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