The West Indies allrounder has been struck down with a groin injury and will miss the final four games of the tournament
Dwayne Bravo will miss the remainder of Chennai Super Kings' Indian Premier League campaign with a groin injury.
The West Indies allrounder suffered the blow against Delhi Capitals over the weekend and missed the clash with Rajasthan Royals.
Scans have since revealed the 37-year-old has suffered a grade one muscle tear and will leave at the United Arab Emirates at the earliest available opportunity.
CSK chief-executive Kasi Viswanaathan told ANI: "No, Bravo isn't playing any more part this time around and the groin injury has ruled him out. He will be flying back in a day or two."
A regular in the latter stages of the IPL, Super Kings are on course for their worst-ever finish in the competition's history.
Three wins from their 10 games leaves them bottom of the table, with hopes of qualifying for the play-offs slipping away.
Prior to the 13th edition of the IPL both Harbhajan Singh and Suresh Raina pulled out of the competition for personal reasons, leaving CSK without two hugely experienced figures.
"Undoubtedly Raina and Harbhajan are both vital cogs in the CSK unit and they were missed," added Viswanaathan.
"But you have to respect personal decisions and that is how we function irrespective of whether it is a senior or junior player."