The captain was unable to train with the squad on Sunday ahead of the clash at St George's Park, which starts on Thursday
England captain Joe Root is a fitness concern ahead of the third Test against South Africa after missing training on Sunday with a stomach bug.
The 29-year-old stayed at the team hotel instead of working with the rest of the squad and is expected to be kept in quarantine away from the main group.
It brings the number of players and staff to have suffered from flu-like symptoms on tour to 17.
Additionally, Rory Burns and James Anderson have been forced out of the tour due to injury, while Jofra Archer has been struggling with an elbow problem.
St George's Park in Port Elizabeth will host the third Test, with the series locked at 1-1 after England beat The Proteas by 189 runs in Cape Town.